Higher levels of the amino acid tyrosine are associated with shorter lifespans in men, according to a recent study. Researchers analyzed data from over 270,000 individuals. They found that elevated tyrosine levels could reduce a man's life expectancy by nearly one year.
The study, published in the journal *Aging-US*, investigated the amino acids phenylalanine and tyrosine. These are building blocks of proteins. They are found in many foods and in dietary supplements. Tyrosine helps produce neurotransmitters like dopamine and norepinephrine. These chemicals affect mood, attention, and stress response.
The research team used data from the UK Biobank. They examined observed relationships between amino acid levels and mortality. They also used Mendelian randomization. This genetic technique helps determine cause-and-effect relationships. This dual approach provided stronger evidence for the findings.
Initially, both phenylalanine and tyrosine showed associations with increased mortality risk. After further analysis, only tyrosine maintained a consistent link to lifespan. This association was observed exclusively in men. Women did not show a similar pattern. Men generally have higher tyrosine levels than women. This difference may partly explain the observed sex-based disparity in average lifespan.
The exact mechanism by which tyrosine influences lifespan is not yet fully understood. Potential explanations include its role in insulin resistance. Insulin resistance is linked to age-related health issues. Tyrosine may also affect neurotransmitter production related to stress response. Hormone-related pathways, which differ between sexes, could also play a role.
This study did not directly examine tyrosine supplements. It focused on naturally occurring blood levels of the amino acid. The findings suggest that elevated tyrosine levels warrant further investigation. Future research will explore whether dietary changes or other interventions can safely lower tyrosine levels. This could potentially promote healthier aging.
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