Vanderbilt researchers developed two new compounds to study the TAOK protein family, linked to Alzheimer's disease, potentially revealing new disease mechanisms and treatment strategies.
Scientists have identified a biological tipping point in microglial behavior that may determine whether Alzheimer's pathology leads to dementia, offering new treatment targets.
Scientists have mapped every neural connection in an adult fruit fly's central nervous system, revealing that behaviors are largely driven by local neural circuits rather than a central brain command.
Scientists at ETH Zurich identified a new Alzheimer's trigger and developed an experimental compound that slowed nerve cell loss and extended lifespan in mice.
Scientists have identified acetylcholine as a key brain chemical that helps individuals break bad habits and adapt to new situations, with implications for treating addiction and neurological disorders.
Scientists have discovered a molecular switch involving the STING protein that drives brain inflammation in Alzheimer's disease, offering a new target for treatments.
Researchers developed a nasal spray that reversed brain aging and improved memory in test models by reducing inflammation and restoring cellular energy.
A brain protein called Menin may drive aging and cognitive decline, and its restoration or a D-serine supplement reversed some effects in mice.
Scientists have identified the enzyme IDOL as a potential new target for Alzheimer's treatment, finding that its removal from neurons significantly reduced amyloid plaques and improved brain resilience in lab studies.
New neuron imaging research has uncovered an unconventional protein transport route called transcytosis, vital for synaptic communication and nerve function.
A new AI-powered computational method, SpaMosaic, unifies fragmented cell data into comprehensive spatial atlases, accelerating the mapping of the body's cells and predicting unmeasured molecular layers.
A new study reveals that the amino acid arginine can significantly reduce toxic amyloid protein buildup and inflammation in animal models of Alzheimer's disease.
Researchers discovered that boosting a protein called Sox9 helps the brain's astrocytes clear Alzheimer's plaques and preserve cognitive function in mice.
A new study suggests that EPA, an omega-3 fatty acid in fish oil, may hinder the brain's repair process after repeated mild traumatic brain injuries.
Harvard Medical School researchers found that the gut bacterium *Morganella morganii* can contribute to depression by producing an inflammation-triggering molecule when exposed to the environmental contaminant diethanolamine (DEA).
Researchers identified two types of brain cells, excitatory neurons and microglia, that show altered activity in people with depression, offering new biological insights.